We recently identified two new biomarker profiles for viability and
cytotoxicity that circumvent many historical assay chemistry limitations and greatly facilitate multiplex measurements. These markers have proteolytic activities associated
with cell death or viability and can be measured in multiplex using either a single luminogenic substrate with sequential reads, a luminogenic substrate in combination
with a fluorogenic substrate, or with two different fluorogenic substrates.
Cell Notes 19, 16–20.
Andrew Niles, Michael Scurria, Laurent Bernad, Brian McNamara, Kay Rashka, Deborah Lange, Pam Guthmiller and Terry Riss
Promega Corporation and Promega Biosciences